Pancreatic cancer is one of the worsts. It is often detected late, spreads rapidly, and has a poor prognosis. There are no symptoms in the early stages. Later stages are associated with symptoms, but these can be non-specific. New treatments are badly needed. Singh Biotechnology is developing a new treatment approach that can shut off the “master switch” that controls cancer growth. This is could revolutionize how we treat deadly cancers like pancreatic.
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Cancer researchers, biotech innovators and pharmaceutical companies have been searching for the “cure” over the past five decades. While a silver bullet cancer cure has not been identified, many candidate treatments for various cancers have entered the market ranging from chemo to immune based therapies.
The currently marketed cancer drugs work by sabotaging a particular protein or “target” that is essential for cancer cell survival. Unfortunately, the approach of targeting one component of a cell system is a fundamental flaw in how we develop drugs because the cancer cell will almost certainly find an opportunity for a work-around. For this reason, current cancer drugs lose their killing powers allowing tumors to return in a more aggressive and malignant response.
Singh Biotechnology is designing cancer drugs differently so that cancer cells cannot escape their drug’s killing effects. Singh’s approach is to create drugs that shut down the “master switch” of cancer cell growth, similar to shutting off the master switch of an electric circuit breaker box. Once the master switch is in the off position, all cellular pathways for growth are shut down, leaving cancer cells no ability to work around.
Importantly, Singh’s drugs are small, so small that they can in fact permeate all cells, including those in the brain and eyes, while leaving normal cells unharmed. These organs have been traditionally difficult to treat because existing drugs are too big to cross the cell membrane, the blood brain barrier and the blood retina membrane.
Singh’s lead drug candidate is called SBT-100 and has already shown preliminary success in animal models for various cancers, including hard to treat cancers such as pancreatic.
Singh Biotechnology has already received Orphan Drug designations from the U.S. Food and Drug Administration (FDA) for pancreatic cancer and osteosarcoma. Therefore pancreatic cancer and osteosarcoma (which are considered rare cancers) will be the first cancer we test with our novel drug.
Singh has also obtained a favorable FDA review for a “pre-IND” briefing packet, which included preclinical data in triple negative breast cancer (TNBC), details about the manufacturing process for, and a proposal for toxicology studies in two species.
We are now raising funds to complete the required toxicology studies and move into phase one clinical trials for triple negative breast cancer.
The raised funds will be used for:
Singh Biotechnology is a virtual company therefore all studies are being performed by independent contractors or scientific collaborators. We have already identified a contract manufacturing organization (CMO) and contract research organization (CRO) to aid us in conducting the toxicology studies and enter phase 1 clinical trials.
Funds raised on the Music Beats Cancer platform would solely be used for the advancement of our lead asset, SBT-100, by conducting the studies outlined above.
There is a public misconception that cancer has not been cured because the “cure” has not been found. The truth is there have been hundreds of cancer treatments that have entered the market since 1971, when then President Nixon declared war on cancer. Many of these drugs unfortunately lose their potency because cancer cells figure out how to avoid the drug’s killing effects.
Singh Biotechnology’s SBT-100 however has the potential to maintain its drug killing effects by completely shutting down the cell’s ability to grow and divide. Therefore SBT-100 is positioned to revolutionize cancer treatment and significantly ease both the physical and economic burdens endured by society. If this technology fails to get funding, it would be a tremendous setback for science, medicine and most importantly for patients in need of treatment options.
Media Interviews:
Press Releases:
https://www.singhbiotechnology.com/pdf/nature-article-single-domain-antibodies.pdf
https://www.singhbiotechnology.com/osteosarcoma.html
http://www.singhbiotechnology.com/pancreatic-cancer-orphan-drug-press-release.html
https://www.singhbiotechnology.com/pdf/miniature-antibody-is-curative-for-autoimmune-uveitis.pdf
Articles published in Scientific/Medical Journals:
https://doi.org/10.1177/1178223417750858
https://doi.org/10.3389/fimmu.2021.724609
Published patents:
Singh Biotechnology Patent Numbers:
Founder & CEO/President
Dr. Singh was a practicing physician / surgeon for 20+ years, prior to founding Singh Biotechnology in 2012. He has also served as Director of Cancer Immunology for GLG Pharma. He incorporated Singh Biotechnology in 2014 and became its full time CEO/President at the end of 2020. Dr. Singh received his M.D. & Ph.D. (in tumor immunology) from the University of Chicago.
Vice President of Research & Development
Mr. Parihar has 25+ years experience in Drug Discovery & Development within the Biotechnology / Pharmaceutical industry including Abbott, Wyeth, Pfizer. He has a diverse scientific background with an emphasis in pharmacology, immunology, and neuroscience.
Vice President of Finance & Marketing
A distinguished business professional with 30+ years of experience. Mr. Dobbs has held senior executive level leadership positions in the investment banking, manufacturing, and advertising industries at Merrill Lynch, Prudential, etc. He is a Certified Financial Manger has an MBA in Communication and Leadership.
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Music Beats Cancer is a 501(c)(3) nonprofit organization. Tax ID #45-4642925
Music Beats Cancer is a 501(c)(3) nonprofit organization. Tax ID #45-4642925
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